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Article

Treg plasticity and human diseases.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Dec 2023

Zhang Zheng, Guo Jihua, Jia Rong

Abstract excerpt

INTRODUCTION: As a subset of CD4+ T cells, regulatory T cells (Tregs) with the characteristic expression of transcription factor FOXP3 play a key role in maintaining self-tolerance and regulating immune responses. However, in some inflammatory circumstances, Tregs can express cytokines of other T help (Th) cells by internal reprogramming, which is called Treg plasticity. These reprogrammed Tregs with impaired...

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PMID: 37878023
DOI: 10.1007/s00011-023-01808-x

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