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Article

Multifaceted HIV‐1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s

14 Sept 2020

Abstract excerpt

APOBEC3 (A3) proteins are a family of host antiviral restriction factors that potently inhibit various retroviral infections, including human immunodeficiency virus (HIV)-1. To overcome this restriction, HIV-1 virion infectivity factor (Vif) recruits the cellular cofactor CBFβ to assist in targeting A3 proteins to a host E3 ligase complex for polyubiquitination and subsequent proteasomal degradation. Intervention...

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PMID: 32893454
DOI: 10.1111/febs.15550

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