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Article

Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase

4 Jan 2023

Abstract excerpt

Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) breaches this host A3G immunity by hijacking a cellular E3 ubiquitin ligase complex to target A3G for ubiquitination and degradation. The molecular mechanism of A3G targeting by Vif-E3 ligase is unknown, limiting the antiviral...

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PMID: 36598981
DOI: 10.1126/sciadv.ade3168

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