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Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and function

2025-07-04

Abstract excerpt

<h4>SUMMARY</h4> The involvement of microglia in neurodegenerative diseases has drawn increasing attention, as many genetic risk factors are preferentially expressed in microglia. Microglial fractalkine receptor (CX3CR1) signaling regulates many key microglial functions, and the CX3CR1-V249I single nucleotide polymorphism (SNP) has been associated with increased risk for multiple neurodegenerative conditions, inc...

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Literature Corpus work
1cc6cb57-4dc7-53df-8526-b5093f6dbc21
DOI
10.1101/2025.07.01.662163
Open publication

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Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and functionDOI 10.1101/2025.07.01.662163
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