Article
The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.
The Journal of experimental medicine - 1 Nov 1995
Papavasiliou F, Jankovic M, Suh H, Nussenzweig M C
Abstract excerpt
In mature B cells, signals transduced through membrane immunoglobulin (Ig) produce cellular activation, yet the same receptor can also mediate deletion and silencing of autoreactive B cells. In addition, Ig expression during the antigen-independent phase of B cell development regulates the precur...
Topics
- Alleles
- Animals
- Antigens, CD
- B-Lymphocytes
- CD79 Antigens
- Cell Differentiation
- Clonal Deletion
- Genes, Immunoglobulin
- H-2 Antigens
- Hematopoietic Stem Cells
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Mice
- Mice, Transgenic
- Peptide Fragments
- Protein Structure, Tertiary
- Receptors, Antigen, B-Cell
- Recombinant Fusion Proteins