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Article

Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.

The EMBO journal - 16 Sept 1996

Hendriks R W, de Bruijn M F, Maas A, Dingjan G M, Karis A, Grosveld F

Abstract excerpt

Bruton's tyrosine kinase (Btk) is a cytoplasmic protein kinase that is defective in X-linked agammaglobulinaemia in man and in X-linked immunodeficiency in the mouse. There is controversy regarding the stages of B cell development that are dependent on Btk function. To determine the point in B cell differentiation at which defects in Btk become apparent, we generated a mouse model by inactivating the Btk gene...

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Identifiers

PMID: 8890160
PMCID: PMC452224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.PMID 8890160Read ↗

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Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children.Semantic proximity Read ↗

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