Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.

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Article

Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.

The EMBO journal - 16 Sept 1996

Hendriks R W, de Bruijn M F, Maas A, Dingjan G M, Karis A, Grosveld F

Abstract excerpt

Bruton's tyrosine kinase (Btk) is a cytoplasmic protein kinase that is defective in X-linked agammaglobulinaemia in man and in X-linked immunodeficiency in the mouse. There is controversy regarding the stages of B cell development that are dependent on Btk function. To determine the point in B ce...

Topics

Agammaglobulinaemia Tyrosine Kinase
Agammaglobulinemia
Alleles
Animals
B-Lymphocytes
Blotting, Western
Cell Differentiation
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Genes, Reporter
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin D

Immunoglobulin M

Lac Operon

Male

Mice

Phenotype

Source

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Identifiers

PMID: 8890160
PMCID: PMC452224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8890160-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.PMID 8890160Read ↗

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The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.Semantic proximity Read ↗

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The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stagesSemantic proximity Read ↗

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