Article
Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.
Nature immunology - 1 Sept 2001
Skok J A, Brown K E, Azuara V, Caparros M L, Baxter J, Takacs K, Dillon N, Gray D, Perry R P, Merkenschlager M, Fisher A G
Abstract excerpt
Individual B lymphocytes normally express immunoglobulin (Ig) proteins derived from single Ig heavy chain (H) and light chain (L) alleles. Allelic exclusion ensures monoallelic expression of Ig genes by each B cell to maintain single receptor specificity. Here we provide evidence that at later stages of B cell development, additional mechanisms may contribute to prioritizing expression of single IgH and IgL...
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