Article
A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells
2018-12-10
Abstract excerpt
To ensure proper transmission of genetic information, cells need to preserve and faithfully replicate their genome, and failure to do so leads to genome instability, a hallmark of both cancer and aging. Defects in genes involved in guarding genome stability cause several human progeroid syndromes, and an age-dependent accumulation of mutations has been observed in different organisms, from yeast to mammals. Howeve...
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Identifiers and source
- Literature Corpus work
- 4c919236-25c6-50c0-a19b-4b64c9afd029
- DOI
- 10.1101/492587