Article
A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease.
G3 (Bethesda, Md.) - 7 Jan 2020
Graves Hillary K, Jangam Sharayu, Tan Kai Li, Pignata Antonella, Seto Elaine S, Yamamoto Shinya, Wangler Michael F
Abstract excerpt
Peroxisomes are subcellular organelles that are essential for proper function of eukaryotic cells. In addition to being the sites of a variety of oxidative reactions, they are crucial regulators of lipid metabolism. Peroxisome loss or dysfunction leads to multi-system diseases in humans that strongly affect the nervous system. In order to identify previously unidentified genes and mechanisms that impact...
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