Article

Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

2021-03-27

Abstract excerpt

Plasma membrane damage (PMD) occurs in all cell types due to environmental perturbation and cell-autonomous activities. However, cellular outcomes of PMD remain largely unknown except for recovery or death. Here, using budding yeast and normal human fibroblasts, we show that cellular senescence, irreversible cell cycle arrest contributing to organismal aging, is the long-term outcome of PMD. To identify the genes...

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Literature Corpus work: d2547700-08ac-568a-aacf-281459daf8aa
DOI: 10.1101/2021.03.26.437120

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