Article
A microarray-based genetic screen for yeast chronological aging factors.
PLoS genetics - 22 Apr 2010
Matecic Mirela, Smith Daniel L, Pan Xuewen, Maqani Nazif, Bekiranov Stefan, Boeke Jef D, Smith Jeffrey S
Abstract excerpt
Model organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the budding yeast, Saccharomyces cerevisiae, in a large-scale screen for genes that function in the regulation of chronological lifespan, which is defined by the number of days that non-dividing cells remain viable. A pooled collection of viable haploid gene...
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