Article

Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing

2022-09-19

Abstract excerpt

<h4> S ummary </h4> Somatic mutations accumulate in multiple organs and tissues during aging and are a known cause of cancer. Here we tested whether mutations accumulate during replicative senescence. Cellular senescence is also a possible cause of functional decline in aging, yet also acts as an anti-cancer mechanism in vivo . Using single-cell whole-genome sequencing, we compared mutation burdens between ear...

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Literature Corpus work: fb029888-735d-537d-8435-b56e35018d22
DOI: 10.1101/2022.09.16.508266

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