Article
A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.
Aging cell - 1 Feb 2020
Novarina Daniele, Janssens Georges E, Bokern Koen, Schut Tim, van Oerle Noor C, Kazemier Hinke G, Veenhoff Liesbeth M, Chang Michael
Abstract excerpt
To ensure proper transmission of genetic information, cells need to preserve and faithfully replicate their genome, and failure to do so leads to genome instability, a hallmark of both cancer and aging. Defects in genes involved in guarding genome stability cause several human progeroid syndromes, and an age-dependent accumulation of mutations has been observed in different organisms, from yeast to mammals....
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