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Article

Mapping epigenetic mutations in fission yeast using whole-genome next-generation sequencing.

Genome research - 1 Jun 2009

Irvine Danielle V, Goto Derek B, Vaughn Matthew W, Nakaseko Yukinobu, McCombie W Richard, Yanagida Mitsuhiro, Martienssen Rob

Abstract excerpt

Fission yeast is an important model for epigenetic studies due to the ease with which genetic mutants can be isolated. However, it can be difficult to complement epigenetic phenotypes with genomic libraries in order to identify the genes responsible. This is because epigenetic phenotypes are typically unstable, and can prohibit complementation if silencing cannot be reestablished. Here we have resequenced the...

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Identifiers

PMID: 19423874
DOI: 10.1101/gr.089318.108
PMCID: PMC2694473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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