Article

Quantitative adaptor heterogeneity sets single-cell thresholds for innate immune activation and attenuation

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>Macrophages exhibit a range of time-dependent responses to external stimuli, but at the single cell-level how receptor input is converted into heterogeneous inflammatory outputs, and how termination occurs remains unclear. Toll-like receptor (TLR) signaling is initiated through supramolecular protein assemblies. In this work, using macrophages with endogenously tagged myeloid differenti...

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Literature Corpus work: 4c799f6c-13a3-52d9-8125-2a9c9ee67494
DOI: 10.21203/rs.3.rs-10682444/v1

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