Article

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threats

2020-05-26

Abstract excerpt

Acute and chronic inflammatory pathologies involve misregulation of macrophage functions. Physiologically, macrophages are immune sentinels that initiate inflammatory responses via the transcription factor NFκB. The temporal pattern of NFκB activity determines which genes are expressed, suggesting that a temporal signaling code specifies a stimulus-appropriate immune response. To identify the signaling codewords,...

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Literature Corpus work: 15b4af52-b8bc-52c2-8a68-e3e47a60a783
DOI: 10.1101/2020.05.23.112862

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