Article

Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11

2020-02-20

Abstract excerpt

An enduring problem in biology is explaining how the functions of genes originated and how those functions diverge between species. Despite detailed studies on the functional evolution of a few proteins, the molecular mechanisms by which protein functions have evolved are almost entirely unknown. Here we show that a polyalanine tract in the homeodomain transcription factor HoxA11 arose in the stem-lineage of mamma...

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Identifiers and source

Literature Corpus work: 7351eeef-9e72-5078-9259-3b7241b58b4e
DOI: 10.1101/2020.02.19.956243

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