Article
Structural Insight into the Binding of TGIF1 to SIN3A PAH2 Domain through a C-Terminal Amphipathic Helix.
International journal of molecular sciences - 23 Nov 2021
He Xiaoling, Nie Yao, Zhou Heng, Hu Rui, Li Ying, He Ting, Zhu Jiang, Yang Yunhuang, Liu Maili
Abstract excerpt
TGIF1 is a transcriptional repressor playing crucial roles in human development and function and is associated with holoprosencephaly and various cancers. TGIF1-directed transcriptional repression of specific genes depends on the recruitment of corepressor SIN3A. However, to date, the exact region of TGIF1 binding to SIN3A was not clear, and the structural basis for the binding was unknown. Here, we demonstrate...
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