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Article

FUS reads histone H3K36me3 to regulate alternative polyadenylation.

Nucleic acids research - 10 Jun 2024

Jia Junqi, Fan Haonan, Wan Xinyi, Fang Yuan, Li Zhuoning, Tang Yin, Zhang Yanjun, Huang Jun, Fang Dong

Abstract excerpt

Complex organisms generate differential gene expression through the same set of DNA sequences in distinct cells. The communication between chromatin and RNA regulates cellular behavior in tissues. However, little is known about how chromatin, especially histone modifications, regulates RNA polyadenylation. In this study, we found that FUS was recruited to chromatin by H3K36me3 at gene bodies. The H3K36me3...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38499486
DOI: 10.1093/nar/gkae184
PMCID: PMC11162772

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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