Article

Inherently reduced expression of ASC restricts caspase-1 processing in hepatocytes and promotes <i>Plasmodium</i> infection

2023-07-10

Abstract excerpt

Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in the hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so, or how it impacts Plasmodium control in the liver has remained unknown. We show th...

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Literature Corpus work: 4c3c1380-8360-5fcb-abb4-e7fff649b643
DOI: 10.1101/2023.07.10.548445

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