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Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum.

Microbes and infection - 1 Jan 2000

McNair Nina N, Bedi Chetna, Shayakhmetov Dmitry M, Arrowood Michael J, Mead Jan R

Abstract excerpt

Cryptosporidium spp. are opportunistic protozoan parasites that infect epithelial cells in the intestinal tract and cause a flu-like diarrheal illness. Innate immunity is key to limiting the expansion of parasitic stages early in infection. One mechanism in which it does this is through the generation of early cytokines, such as IL-18. The processing and secretion of mature IL-18 (and IL-1β) is mediated by...

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PMID: 29842985
DOI: 10.1016/j.micinf.2018.04.006

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