Article
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.
Gut - 1 Feb 2018
Triantafyllou Evangelos, Pop Oltin T, Possamai Lucia A, Wilhelm Annika, Liaskou Evaggelia, Singanayagam Arjuna, Bernsmeier Christine, Khamri Wafa, Petts Gemma, Dargue Rebecca, Davies Scott P, Tickle Joseph, Yuksel Muhammed, Patel Vishal C, Abeles Robin D, Stamataki Zania, Curbishley Stuart M, Ma Yun, Wilson Ian D, Coen Muireann, Woollard Kevin J, Quaglia Alberto, Wendon Julia, Thursz Mark R, Adams David H, Weston Chris J, Antoniades Charalambos G
Abstract excerpt
OBJECTIVE: Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution of acute hepatic inflammation are largely unknown. Here, we aimed to investigate the impact of Mer tyrosine kinase (MerTK) during ALF and also examine how the microenvironmental mediator, secretory leucocyte...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.