Article

IL-1b drives SARS-CoV-2 disease in vivo, independently of the inflammasome and pyroptotic signalling

2024-08-28

Abstract excerpt

<title>Abstract</title> <p>Excessive inflammation and cytokine release are hallmarks of severe COVID-19. Programmed cell death processes can drive inflammation, however, the relevance in the pathogenesis of severe COVID-19 is unclear. Pyroptosis is a pro-inflammatory form of regulated cell death initiated by inflammasomes and executed by the pore-forming protein gasdermin D (GSDMD). Using an established mouse-ada...

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Literature Corpus work: d0d54a1c-4ab0-56ab-b8f2-11eae665f273
DOI: 10.21203/rs.3.rs-4826453/v1

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