Article

Evolution of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling

2025-11-01

Abstract excerpt

The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and are key to controlling intracellular and extracellular infections. Human caspase-4 and -5 are cysteine proteases activated upon intracellular detection of bacterial lipopolysaccharide (LPS) and triggers pyroptosis, a...

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Identifiers and source

Literature Corpus work: 7351ee0d-269a-5822-b122-edf0f00aefc5
DOI: 10.1101/2025.11.01.685735

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