An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.

doi:10.1016/j.ajpath.2015.12.026

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Article

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.

The American journal of pathology - 1 May 2016

Nastase Madalina-Viviana, Zeng-Brouwers Jinyang, Frey Helena, Hsieh Louise Tzung-Harn, Poluzzi Chiara, Beckmann Janet, Schroeder Nina, Pfeilschifter Josef, Lopez-Mosqueda Jaime, Mersmann Jan, Ikeda Fumiyo, Iozzo Renato V, Dikic Ivan, Schaefer Liliana

Abstract excerpt

Sepsis is burdened by high mortality due to uncontrolled inflammatory response to pathogens. Increased caspase 1 activation causing maturation of IL1β/18 remains a therapeutic challenge in sepsis. SHARPIN (shank-associated regulator of G-protein signaling homology domain-interacting protein), a component of the LUBAC (linear ubiquitin chain-assembly complex), regulates inflammation, with unknown effects on...

Topics

Animals
Caspase 1
Caspase Inhibitors
Caspases
Caspases, Initiator
Cells, Cultured
Dermatitis
Down-Regulation
Endotoxemia
Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-18

Interleukin-1beta

Leukocytes, Mononuclear

Lipopolysaccharides

Lung

Mice, Inbred C57BL

Mice, Knockout

NF-kappa B

Source

Open in PubMed

Identifiers

PMID: 26968342
DOI: 10.1016/j.ajpath.2015.12.026

Genes

SHARPIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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