Article

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria

2024-10-24

Abstract excerpt

Plasmodium parasites undergo development and replication within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) are known to hinder Plasmodium infection within the liver, the underlying mechanisms remain unclear. Here, we describe two IFN-I-driven hepatocyte antimicrobial programs controlling liver-stage malaria. First, oxidative defense by NAD...

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Identifiers and source

Literature Corpus work: 42359578-6787-5a1d-89c9-02ae43096747
DOI: 10.1101/2024.10.22.619707

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