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Article

Dynamics of in vivo ASC speck formation.

The Journal of cell biology - 4 Sept 2017

Kuri Paola, Schieber Nicole L, Thumberger Thomas, Wittbrodt Joachim, Schwab Yannick, Leptin Maria

Abstract excerpt

Activated danger or pathogen sensors trigger assembly of the inflammasome adaptor ASC into specks, large signaling platforms considered hallmarks of inflammasome activation. Because a lack of in vivo tools has prevented the study of endogenous ASC dynamics, we generated a live ASC reporter through CRISPR/Cas9 tagging of the endogenous gene in zebrafish. We see strong ASC expression in the skin and other epithelia...

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Identifiers

PMID: 28701426
DOI: 10.1083/jcb.201703103
PMCID: PMC5584180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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