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sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

2021-07-13

Abstract excerpt

<title>Abstract</title> <p>Background Tumor necrosis factor (TNF)-α inhibitors represented by etanercept (a fusion protein containing soluble TNF receptor Ⅱ (sTNFRⅡ) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (RA) treatment. However, long-term use increases the risk of infection and tumors for their systemic inhibition of TNF-α, which disrupts the regular physiological function...

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Literature Corpus work
4c30f5ed-6e49-52fd-90da-2306dc2299f4
DOI
10.21203/rs.3.rs-695405/v1
Open publication

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