Article

Targeted protein degradation via CAR endocytosis of antigen in T cells

2024-11-21

Abstract excerpt

Targeted protein degradation (TPD) relies on molecules engaging host protein degradation machinery. Here, we developed a novel TPD platform based on antigen endocytosis and degradation by chimeric antigen receptor (CAR) T cells. T cells expressing a CAR with TNFR1 as the antigen-binding domain (TNFR1T) were able to bind, endocytose, and degrade TNF in vitro. To enhance in vivo expansion and persistence of TNFR1T c...

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Literature Corpus work: 9b6d3f1e-8ae4-550a-ae7d-40237dbec1f9
DOI: 10.1101/2024.11.20.624443

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