Tumor necrosis factor receptor 1 is required for human umbilical cord-derived mesenchymal stem cell-mediated rheumatoid arthritis therapy

Abstract excerpt

<title>Abstract</title><p>Background Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) can relieve the symptoms of rheumatoid arthritis. However, we did not know whether TNFR1 expressed by hUC-MSCs contributes to therapy as a neutralizer of TNF-α or whether TNFR1 has more roles. This study aimed to explore the functions of TNFR1 in hUC-MSC-mediated RA therapy. Methods We knocked down TNFR1 in hUC-MSCs...

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• Cancer-related molecular mechanisms research
• CAR-T cell therapy research
• Coculture Techniques
• Cytokine Signaling Pathways and Interactions
• Immune Response and Inflammation
• Immunotherapy and Immune Responses
• NF-κB Signaling Pathways
• Osteoarthritis Treatment and Mechanisms

Identifiers and source

Literature Corpus work

96602c5f-022d-597b-96bc-cf86b6fe41a6

DOI

10.21203/rs.3.rs-3294230/v1