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An innovative immunotherapeutic strategy for rheumatoid arthritis: selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1

2022-09-28

Abstract excerpt

<h4>Background: </h4> Thymocyte antigen-1 (THY-1) is a potential therapeutic target for rheumatoid arthritis (RA) treatment, and THY-1 positive fibroblast-like synoviocytes (FLS) are enriched in the synovium of RA patients and participate in angiogenesis to accelerate rheumatoid arthritis development. In this study, we screened a full human antibody targeting THY-1 and exploring its anti-RA activity and mechanism....

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Literature Corpus work
4f451d63-c26f-59a1-aefc-a8d64f95ea83
DOI
10.21203/rs.3.rs-2092718/v1
Open publication

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An innovative immunotherapeutic strategy for rheumatoid arthritis: selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1DOI 10.21203/rs.3.rs-2092718/v1
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