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Article

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.

Biomaterials - 1 Dec 2009

Shibata Hiroko, Yoshioka Yasuo, Abe Yasuhiro, Ohkawa Akiko, Nomura Tetsuya, Minowa Kyoko, Mukai Yohei, Nakagawa Shinsaku, Taniai Madoka, Ohta Tsunetaka, Kamada Haruhiko, Tsunoda Shin-ichi, Tsutsumi Yasuo

Abstract excerpt

Blocking the binding of TNF-alpha to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA). We recently succeeded in developing a TNFR1-selective antagonistic TNF mutant, R1antTNF. Here, we report the anti-inflammatory effects of R1antTNF in a murine collagen-induced arthritis model. To improve the in vivo stability of R1antTNF, we first engineered PEG...

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Source

Identifiers

PMID: 19765818
DOI: 10.1016/j.biomaterials.2009.08.041

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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