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Article

Stem Cell-Derived Exosomes with High Expression of PD-L1 as Nanotherapeutics in Rheumatoid Arthritis Model Mice

1 Jul 2025

Abstract excerpt

Purpose: Previous studies have identified synovial T cells as key pathogenic drivers of rheumatoid arthritis (RA). To explore a novel therapeutic strategy targeting these cells, we aimed to develop mesenchymal stem cell-derived exosomes with enhanced PD-L1 expression (Exo-PD-L1) and evaluate their therapeutic potential in RA. Methods: Mouse bone marrow mesenchymal stem cells (MSCs) were stimulated with interferon...

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PMID: 40665963
DOI: 10.2147/ijn.s522245

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