Article

Traip Mitotic Function Controls Brain Size

2021-07-07

Abstract excerpt

Microcephaly is a developmental failure to achieve proper brain size and neuron number. Mutations in diverse genes are linked to microcephaly, including several with DNA damage repair (DDR) functions; however, it is not well understood how these DDR gene mutations limit brain size. One such gene is TRAIP , which has multiple known functions in DDR. We characterized the Drosophila ortholog Traip , finding that l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c1431fe-6f2e-56f6-90d2-825e301525d6
DOI: 10.1101/2021.07.07.451466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Traip Mitotic Function Controls Brain SizeDOI 10.1101/2021.07.07.451466Read

A pivotal contribution of proteostasis failure and mitochondrial dysfunction to chromosomal instability-induced microcephalySemantic proximity Read

The neurodevelopmental transcriptome of the <i>Drosophila melanogaster</i> microcephaly gene <i>abnormal spindle</i> reveals a role for temporal transcription factors and the immune system in regulating brain sizeSemantic proximity Read

The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental DiseasesSemantic proximity Read

Same but different: pleiotropy in centrosome-related microcephaly.Semantic proximity Read

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesisSemantic proximity Read

Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.Semantic proximity Read

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read

Transient lagging chromosomes cause primary microcephalySemantic proximity Read

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.Semantic proximity Read

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.Semantic proximity Read

NUSAP1 regulates mitotic processes via KIF2C interaction and AURKA phosphorylation in primary microcephalySemantic proximity Read

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.Semantic proximity Read