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An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

5 Jan 2023

Abstract excerpt

Entosis is cell cannibalism utilized by tumor cells to engulf live neighboring cells for pro- or anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be pathogenic in other diseases such as microcephaly, a condition characterized by a smaller than normal brain at birth. We find that mice mutant for the human microcephaly-causing gene Pals1, which exhibit diminished cortices due...

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PMID: 36604424
DOI: 10.1038/s41467-022-35719-y

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