Article
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
The EMBO journal - 4 Jan 2021
Phan Thao P, Maryniak Aubrey L, Boatwright Christina A, Lee Junsu, Atkins Alisa, Tijhuis Andrea, Spierings Diana Cj, Bazzi Hisham, Foijer Floris, Jordan Philip W, Stracker Travis H, Holland Andrew J
Abstract excerpt
Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain development, causing microcephaly. While NPC attrition is linked to TP53-mediated cell death in several microcephaly models, how TP53 is activated remains unclear. In cultured cells, mitotic delays resulting from centrosome loss prevent the growth of unfit daughter cells by activating a pathway involving 53BP1, USP28, and TP53,...
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