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Article

The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases

24 Dec 2019

Abstract excerpt

Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how...

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PMID: 31878213
DOI: 10.3390/cells9010049

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