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Article

Same but different: pleiotropy in centrosome-related microcephaly.

Molecular biology of the cell - 1 Feb 2018

O'Neill Ryan S, Schoborg Todd A, Rusan Nasser M

Abstract excerpt

An intimate link between centrosome function and neurogenesis is revealed by the identification of many genes with centrosome-associated functions that are mutated in microcephaly disorders. Consistent with the major role of the centrosome in mitosis, mutations in these centrosome-related microcephaly (CRM) genes are thought to affect neurogenesis by depleting the pool of neural progenitor cells, primarily...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29382806
DOI: 10.1091/mbc.E17-03-0192
PMCID: PMC5996963

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