Article

Transient lagging chromosomes cause primary microcephaly

2024-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Primary microcephaly results from the impaired neuronal progenitor proliferation, causing reduced brain size and impaired cognitive abilities. Loss of the most frequently microcephaly genes, WDR62 and ASPM , slows down poleward microtubule flux and results in transient lagging chromosomes in anaphase. Whether these defects cause primary microcephaly is unknown. Here we show that transient lagg...

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Literature Corpus work: 5090c3a8-7715-5123-9099-1a49a789bb87
DOI: 10.1101/2024.05.02.592199

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