Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A full-length mtDNA dataset for studying genetic variations across generations and complex family structures.

Scientific data - 13 Feb 2026

Liu Yanan, Yang Qi, Xuan Yujia, Zhao Jinyuan, Chen Anqi, Zhang Suhua

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are critical to disease research, evolutionary studies, and lineage tracing but are challenging to analyze due to interference from nuclear mitochondrial sequences (NUMTs). Current high-throughput sequencing techniques rely on multiple primers or probes to amplify short mtDNA fragments, followed by alignment to a reference genome. However, this approach fails to mitigate NUMTs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Genetic Variation
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Pedigree

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 41688488
DOI: 10.1038/s41597-026-06824-0
PMCID: PMC13013646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A full-length mtDNA dataset for studying genetic variations across generations and complex family structures.PMID 41688488Read ↗

Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Semantic proximity Read ↗

Mitochondrial DNA Sequencing and Heteroplasmy Quantification by Next Generation Sequencing.Semantic proximity Read ↗

Mitochondrial Diseases: A Diagnostic Revolution.Semantic proximity Read ↗

Long-read MitoScope reveals tissue-resolved somatic mitochondrial variation and landscape of nuclear-embedded mitochondrial sequencesSemantic proximity Read ↗

High-throughput sequencing in mitochondrial DNA research.Semantic proximity Read ↗

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed casesSemantic proximity Read ↗

Next generation sequencing to characterize mitochondrial genomic DNA heteroplasmy.Semantic proximity Read ↗

North and East African mitochondrial genetic variation needs further characterization towards precision medicineSemantic proximity Read ↗

Extraction and annotation of human mitochondrial genomes from 1000 Genomes Whole Exome Sequencing data.Semantic proximity Read ↗

Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses.Semantic proximity Read ↗

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases.Semantic proximity Read ↗

Mitochondrial DNA variation across 56,434 individuals in gnomADSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.