Article

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

2022-09-29

Abstract excerpt

<h4>Summary</h4> Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. We identified three unrelated boys with perinatal-onset of neutrophilic cutaneous small vessel vasculitis and systemic inflammation. Two patients developed liver fibrosis in their first year of life...

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Literature Corpus work: e94d773b-8c3c-5222-aec4-68f22fb9c03f
DOI: 10.1101/2022.09.27.22280319

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