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Article

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009

Kim Hyun-Ju, Zhang Kaihua, Zhang Lihong, Ross F Patrick, Teitelbaum Steven L, Faccio Roberta

Abstract excerpt

c-Src kinase is a rate-limiting activator of osteoclast (OC) function and Src inhibitors are therefore candidate antiosteoporosis drugs. By affecting alphavbeta3 and macrophage-colony stimulating factor (M-CSF)-induced signaling, c-Src is central to osteoclast activity, but not differentiation. We find Lyn, another member of Src family kinases (SFK) is, in contrast, a negative regulator of osteoclastic bone...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19171907
DOI: 10.1073/pnas.0806963106
PMCID: PMC2650155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.PMID 19171907Read ↗

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Src kinase activity is essential for osteoclast function.Semantic proximity Read ↗

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