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Article

BRAF-V600E utilizes posttranscriptional mechanisms to amplify LPS-induced TNFα production in dendritic cells in a mouse model of Langerhans cell histiocytosis.

Journal of leukocyte biology - 1 Nov 2022

Minichino Danielle, Lv Kaosheng, Chu Niansheng, Tong Wei, Behrens Edward M

Abstract excerpt

Langerhans cell histiocytosis (LCH) is an inflammatory disease characterized by abnormal dendritic cells (DCs) with hyperactive ERK signaling, called "LCH cells." Since DCs rely on ERK signaling to produce inflammatory molecules in response to pathogenic cues, we hypothesized that hyperactive ERK enhances DCs inflammatory responses. We specifically investigated TLR4-induced TNFα production in LCH cells by...

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Share to Dendritic Cells
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 35648675
DOI: 10.1002/JLB.3A0122-075RR
PMCID: PMC9939017

Genes

BRAF
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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