Article

Mitigation of the age-dependent decline in mitochondrial genome integrity

2022-01-20

Abstract excerpt

Unknown processes promote accumulation of mitochondrial DNA mutations during aging. Accumulation of defective mitochondrial genomes is thought to promote progression of heteroplasmic mitochondrial diseases and degenerative changes with natural aging. We used a heteroplasmic Drosophila model to test 1) whether purifying selection acts to limit the abundance of deleterious mutations during development and aging, 2)...

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Literature Corpus work: 4bfc0972-fe59-58b5-8648-4c25ea3df470
DOI: 10.1101/2022.01.18.476860

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