Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.

doi:10.1038/ng.2919

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Article

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster.

Nature genetics - 1 Apr 2014

Ma Hansong, Xu Hong, O'Farrell Patrick H

Abstract excerpt

It is not known how selection affects mutations in the multiple copies of the mitochondrial genome. We transferred cytoplasm between D. melanogaster embryos carrying mitochondrial mutations to create heteroplasmic lines transmitting two mitochondrial genotypes. Increased temperature imposed selection against a temperature-sensitive mutation affecting cytochrome oxidase, driving decreases in the abundance of the...

Topics

Animals
Blotting, Southern
DNA, Mitochondrial
Drosophila melanogaster
Electron Transport Complex IV
Genes, Mitochondrial
Genotype
Models, Genetic
Mutation
Polymerase Chain Reaction
Selection, Genetic
Temperature

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Identifiers

PMID: 24614071
DOI: 10.1038/ng.2919
PMCID: PMC4091738

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