Article

Replication competition drives the selective mtDNA inheritance in <i>Drosophila</i> ovary

2025-05-03

Abstract excerpt

Purifying selection that limits the transmission of harmful mitochondrial DNA (mtDNA) mutations has been observed in both human and animal models. Yet the precise mechanism underlying this process remains undefined. Here, we present a highly specific and efficient in situ imaging method capable of visualizing mtDNA variants that differ by only a few nucleotides at single-molecule resolution in Drosophila ovaries...

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Literature Corpus work: 12bfe4f6-2058-5a32-a87d-115d31ba5882
DOI: 10.1101/2025.04.29.650984

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