Article
The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications.
GigaScience - 1 Jun 2018
Ramnarine Varune Rohan, Alshalalfa Mohammed, Mo Fan, Nabavi Noushin, Erho Nicholas, Takhar Mandeep, Shukin Robert, Brahmbhatt Sonal, Gawronski Alexander, Kobelev Maxim, Nouri Mannan, Lin Dong, Tsai Harrison, Lotan Tamara L, Karnes R Jefferey, Rubin Mark A, Zoubeidi Amina, Gleave Martin E, Sahinalp Cenk, Wyatt Alexander W, Volik Stanislav V, Beltran Himisha, Davicioni Elai, Wang Yuzhuo, Collins Colin C
Abstract excerpt
Background: Treatment-induced neuroendocrine prostate cancer (tNEPC) is an aggressive variant of late-stage metastatic castrate-resistant prostate cancer that commonly arises through neuroendocrine transdifferentiation (NEtD). Treatment options are limited, ineffective, and, for most patients, result in death in less than a year. We previously developed a first-in-field patient-derived xenograft (PDX) model of...
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