Article

Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

2025-02-17

Abstract excerpt

<h4>SUMMARY</h4> Neuroendocrine prostate cancer (NEPC) arises primarily through neuroendocrine transdifferentiation (NEtD) as an adaptive mechanism of therapeutic resistance. Models to define the functional effects of putative drivers of this process on androgen receptor (AR) signaling and NE cancer lineage programs are lacking. We adapted a genetically defined strategy from the field of cellular reprogramming to...

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Literature Corpus work: 271afb6a-5446-5029-8905-6c8e3fd22167
DOI: 10.1101/2025.02.12.637904

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