Article

Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer

2024-12-07

Abstract excerpt

<h4>ABSTRACT</h4> A significant number of castration-resistant prostate cancer (CRPC) evolve into a neuroendocrine (NE) subtype termed NEPC, leading to resistance to androgen receptor (AR) pathway inhibitors and poor clinical outcomes. Through Hi-C analyses of a panel of patient-derived xenograft tumors, here we report drastically different 3D chromatin architectures between NEPC and CRPC samples. Such chromatin...

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Literature Corpus work: 46c19088-566f-5c52-96e1-9df0988f3289
DOI: 10.1101/2024.12.04.626816

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