Article

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

2020-10-24

Abstract excerpt

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism of adaptive resistance to targeted therapy in cancer 1,2 . An archetypal example is the development of neuroendocrine prostate cancer (NEPC) after treatment of prostate adenocarcinoma (PRAD) with inhibitors of androgen signaling. NEPC is an aggressive variant of prostate cancer that aberrantly expresses genes char...

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Literature Corpus work: 50d6c8a0-d495-5102-ada7-c5b386dbaa3e
DOI: 10.1101/2020.10.23.350793

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